These tails are subject to several publish-translational covalent modifications, together with acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ). The exception to the rule is the DOT1 household, members of which methylate K79 lawyers in my area the globular region of histone H3 and which are structurally not related to SET-area proteins 4 - 6 Current work means that SET-domain-containing proteins methylate a few proteins in addition to histones (see later)